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KMID : 0616120160470020158
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Korean Journal of Pharmacognosy
2016 Volume.47 No. 2 p.158 ~ p.164
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Effects of Allium Hookeri Extracts on Glucose Metabolism in Type II Diabetic Mice
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Kim Nam-Seok
Choi Bong-Kyoum
Lee Seon-Hye
Jang Hwan-Hee
Kim Jung-Bong
Kim Haeng-Ran
Choi Jung-Sook
Cho Yong-Sik
Kim You-Suk
Yang Jae-Heon
Kim Young-Soo
Kim Hyun-Ju
Kim Dae-Keun
Lee Chang-Hyun
Lee Sung-Hyun
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Abstract
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This study was conducted to verify the potential of Allium hookeri to control blood glucose metabolism in diabetes model. We fed the experimental diets(ALE, ARE) supplemented with the extract of Allium hookeri leaf or root at 1% of diet to the diabetic mice (C57BLKS/J, db/db) for 8 weeks. Hetero and control mice were fed the control diet without any extract of Allium hookeri leaf or root. At 8th week of feeding the diets, we measured body weight, blood glucose, HbA1c, and plasma insulin levels and conducted an oral glucose tolerance test (OGTT) and staining insulin immunoreactive cells in islets of pancreas. ARE group treated with the root of A. hookeri showed significantly lower blood glucose levels than the Cont group at 120 min in the OGTT. However, HbA1c level was significantly reduced in both ALE and ARE groups, and higher serum insulin levels and increased density of insulin immunoreactive cells compared with the Cont group were found in these 2 groups. Based on these results, A. hookeri is considered to be effective in improving glucose tolerance by partially affecting insulin secretion and it may be used to prevent and treat diabetic disease.
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KEYWORD
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Allium hookeri, Diabetic mice, Glucose, HbA1c, Insulin
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